Риск заболеваний аутического спектра у тех, кто был привит от гепатита B первый месяц жизни, в три раза выше, чем у непривитых или привитых в старшем возрасте.
Опубликовано в журнале "Annals of Epidemiology"
"Hepatitis B Vaccination of Male Neonates and Autism"
Annals of Epidemiology Vol. 19, No. 9 ABSTRACTS (ACE) September 2009: 651-680 p. 659 (Medical research journal. – ed)
CM Gallagher, MS Goodman, Graduate Program in Public Health, Stony Brook University Medical Center, Stony Brook, NY
PURPOSE: Universal newborn immunization with hepatitis B vaccine was recommended in 1991; however, safety findings are mixed. The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events. Other studies found positive associations between hepatitis B vaccination and ear infection, pharyngitis, and chronic arthritis; as well as receipt of early intervention/ special education services (EIS); in probability samples of U.S. children. Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS. We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD.
METHODS: This cross-sectional study used U.S. probability samples obtained from National Health Interview Survey 1997-2002 datasets. Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3-17 years with shot records, adjusted for race, maternal education, and two-parent household.
RESULTS: Boys who received the hepatitis B vaccine during the first month of life had 2.94 greater odds for ASD (nZ31 of 7,486; OR = 2.94; p = 0.03; 95% CI: 1.10, 7.90) compared to later- or unvaccinated boys. Non-Hispanic white boys were 61%less likely to have ASD(OR=0.39; p=0.04; 95% CI: 0.16, 0.94) relative to non-white boys.
CONCLUSION: Findings suggest that U.S. male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD; risk was greatest for non-white boys.
